Abstract: Series 111, Lecture 7

The Harvey Lectures Series 111 (2015—2016)

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Lecture #7: Thursday, May 19, 2016 — Watch Video of Lecture

Visualization of Macromolecular Complexity and Function using Cry-Electron Microscopy

Eva Nogales, PhD

Eva Nogales, PhD

Professor of Biochemistry, Biophysics and Structural Biology
Senior Faculty Scientist at Lawrence Berkeley National Laboratory
Investigator, Howard Hughes Medical Institute

Howard Hughes Medical Institute, University of California, Berkeley

Berkeley, California

Dr Nogales's Website

Cryo-EM is a structural technique rapidly advancing in resolution and applicability to very challenging systems. Because crystallization is not required, very little sample is needed, and the potential to deal with compositional and conformational mixtures, cryo-EM is used to investigate fully functional macromolecular complexes in different functional states, providing a richness of biological insight. We are using cryo-EM towards a structural understanding of transcription initiation and microtubule dynamic instability, two essential processes for eukaryotic cells.