Abstract: Series 112, Lecture 6

The Harvey Lectures Series 112 (2016—2017)

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Lecture #6: Thursday, April 20, 2017 — Watch Video of Lecture

Navigating the Cellular Landscape with New Imaging Technologies

Jennifer Lippincott-Schwartz, PhD

Jennifer Lippincott-Schwartz, PhD

Group Leader
Janelia Research Campus, Howard Hughes Medical Institute

Howard Hughes Medical Institute, Janelia Research Campus

Ashburn, Virginia

Dr Lippincott-Schwartz's Website

New imaging techniques are helping to reveal the complex dynamics of cells, including how multi-scale structural relationships form and self-adjust to changing environmental conditions. In this talk, I will discuss emerging fluorescent technologies that are increasing spatio-temporal resolution and permitting simultaneous multispectral imaging of multiple cellular components. Using these tools, it is now possible to begin constructing an “organelle interactome” describing the interrelationships of different cellular organelles as they carry out critical functions. The same tools are also revealing new properties of the cell’s largest organelle, the endoplasmic reticulum, and how disruptions of its normal function due to genetic mutations may contribute to important diseases.