Abstract: Series 116, Lecture 6

The Harvey Lectures Series 116 (2022—2023)

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Lecture #6: Thursday, April 20, 2023 — Watch Video of Lecture

Biomolecular condensates in physiology and disease

Anthony A. Hyman, PhD

Anthony A. Hyman, PhD


Max Planck Institute of Molecular Cell Biology and Genetics

Dresden, Germany

Dr Hyman's Website

Cells organize many of their biochemical reactions by formation and dissolution of non-membrane-bound compartments. Recent experiments show that one common mechanism for such biochemical organization is phase separation of disordered proteins to form liquid-like compartments. These compartments can subsequently harden to form compartments with new material properties such as gels and glasses. These compartments can be described by principles elucidated from condensed-matter physics and are therefore termed biomolecular condensates. I will discuss potential roles of phase separation in organization and robustness of cellular biochemistry.